Healthcare infrastructure development in frontier markets faces significant challenges, including limited access to capital, systemic inefficiencies, and inadequate investment frameworks. Addressing these barriers requires innovative financing mechanisms that can attract diverse funding sources while ensuring long-term sustainability. This paper explores a blended financing framework that integrates private equity, government funding, and philanthropic capital to unlock capital for sustainable healthcare infrastructure development in emerging economies. The proposed model leverages the strengths of each funding source: private equity drives financial discipline and scalability, government funding ensures alignment with national health priorities, and philanthropic capital provides catalytic support to address funding gaps and promote equity. The framework prioritizes public-private partnerships (PPPs) as a central mechanism for implementation, facilitating collaboration among key stakeholders to balance profitability with social impact. Risk-sharing mechanisms, such as guarantees and outcome-based funding, are highlighted to reduce financial uncertainties and attract private sector investment. Additionally, the model emphasizes leveraging digital technologies to enhance project efficiency and sustainability, including tools for real-time monitoring and data-driven decision-making. This study also identifies enabling policies, such as tax incentives, streamlined regulations, and capacity-building initiatives, that create a conducive environment for blended financing. Case studies from various frontier markets illustrate successful applications of the model, showcasing its scalability and adaptability across different socioeconomic contexts. The findings highlight the role of monitoring and evaluation frameworks in ensuring accountability, measuring impact, and fostering continuous improvement in healthcare delivery. By integrating the strengths of diverse funding sources, the blended financing framework provides a practical and scalable solution to bridge the healthcare infrastructure gap in frontier markets. It aligns private sector incentives with public and philanthropic objectives, ensuring financial viability while addressing systemic inequities. This approach not only fosters sustainable infrastructure development but also strengthens healthcare systems to withstand future economic and environmental challenges.